Abstract: 【Abstract】Renal replacement therapy (RRT) has made great progresses since the last century. RRT is now widely used, especially for acute kidney injury. The main modalities of RRT consist of intermittent hemodialysis (IHD), continuous renal replacement therapy (CRRT), peritoneal dialysis (PD), etc. Each of these modalities has its own advantages and disadvantages. The prolonged intermittent renal replacement therapy (PIRRT) emerges in order to improve the efficiency of RRT. As a hybrid RRT, PIRRT combing the efficiency of IHD and the stable hemodynamics of CRRT is able to clear small solutes with an efficacy comparable to IHD and CRRT, and offers the advantages of flexible time for treatment and reduced medical expenses. Consequently, PIRRT has become one of the hotspots in China and other countries. However, due to the lack of clear guidelines, PIRRT is still faced with significant challenges, especially pertaining to appropriate dialysate volume and drug doses. There should be more clinical trials to develop a unified standard for PIRRT in the future.

Key words: prolonged intermittent renal replacement therapy, acute kidney injury, characteristics, method