Abstract: 【Abstract】Objective To investigate the status of left ventricular diastolic function and to explore the influence factors for left ventricular diastolic dysfunction in patients with maintenance peritoneal dialysis (PD). Methods Cardiac diastolic function was evaluated by color Doppler ultrasound. In the 130 PD patients, 123 patients were diagnosed with grade I or grade II left ventricular diastolic dysfunction according to the findings of color Doppler ultrasound. Demographic characteristics, clinical and laboratory indicators were compared between patients with grade I and grade II left ventricular diastolic dysfunction to analyze the risk factors for left ventricular diastolic dysfunction. Results The prevalence of left ventricular diastolic dysfunction was 94.6%, in which 35.4% were grade II diastolic dysfunction. Body mass index (BMI) (t=- 2.058, P=0.042), blood phosphorus (t=-2.699, P=0.008) and brain natriuretic peptide (BNP) (t=-2.588, P=0.011) were significantly different between the PD patients with grade II and grade I diastolic dysfunction. Logistic regression analysis found that higher levels of BMI (OR=1.316, 95% CI: 1.117～1.550, P=0.001), total cholesterol (OR=2.034, 95% CI: 1.153～3.588, P=0.014), serum phosphorus (OR=3.855, 95% CI: 1.477～10.059, P =0.006) and BNP (OR=1.003, 95% CI: 1.001～1.004, P=0.003) were the risk factors for left ventricular diastolic dysfunction. Conclusions Left ventricular diastolic dysfunction occurred in most PD patients. Higher levels of BMI, total cholesterol, serum phosphorus and BNP were the risk factors for left ventricular diastolic function.

Key words: Peritoneal dialysis, Diastolic dysfunction, Body mass index, Total cholesterol, Phosphorus, Brain natriuretic peptide