Abstract: 【Abstract】Objective To analyze the influencing factors for cognitive function in hemodialysis patients and to establish a predictive model. Methods Montreal cognitive assessment (MoCA) and Pittsburgh sleep quality index (PSQI) were used to assess cognitive function and sleep status in 147 hemodialysis patients who were randomly selected from our center. Results Multivariate logistic regression analysis showed that older age (OR=2.29, P=0.047), lower educational level (OR=6.69, P＜0.001), poor sleep quality (OR=4.01, P=0.001) were the risk factors for cognitive impairment. The area under the receiver operating characteristic curve (AUC) for nomogram predictive model was 0.77. Conclusion Cognitive impairment is common in hemodialysis patients. Older age, lower educational level and poor sleep quality were the independent risk factors for cognitive impairment. Nomogram can accurately predict the risk of cognitive impairment in hemodialysis patients.

Key words: Hemodialysis, Cognition, Risk factor, Predictive model