Abstract: 【Abstract】Peritoneal dialysis (PD) is a widely used renal replacement therapy. As the increase of PD age in the patients, changes of peritoneal function occur, which is characterized by the increase of solute transport and decrease of ultrafiltration. Ultrafiltration failure (UFF) will eventually lead to PD failure. Recurrent peritonitis, prolonged exposure to bioincompatible dialysate and long dialysis age are the major contributors to peritoneal dysfunction. Corresponding anatomical changes in the peritoneum include peritoneal fibrosis, hyalinizing vasculopathy and angiogenesis. Many biomarkers are clinically used to effectively assess and predict changes of peritoneal function. Implementing effective measures to protect peritoneal function can prolong PD age and improve survival rate of PD patients. Recently, strategies to preserve peritoneal membrane function in PD patients have become a new research hotspot. This review briefly describes the latest research progress in strategies to preserve peritoneal membrane function.

Key words: Peritoneal dialysis, biomarkers, preservation of peritoneal membrane function, preventive measure, therapeutic intervention