Abstract: 【Abstract】 Objective To analyze the changes of pathogens and antimicrobial susceptibilities in peritoneal dialysis-related peritonitis. Methods We recruited the peritoneal dialysis-related peritonitis patients treated in the recent 5 years in our department, and retrospectively analyzed their general condition, pathogens, antimicrobial susceptibilities, and prognosis. Results ①In the 46 samples for microbial culture, 24 samples (52.2%) were positive for pathogens, in which Gram-positive bacteria were found in 9 cases (37.5%), Gram-negative bacteria in 8 cases (33.3%), and fungi in 7 cases (29.2%). ②In the isolated Grampositive bacteria, the antibiotic resistance rate to cephalosporins was high, and the rates to vancomycin and teicoplanin were low. In the isolated Gram-negative bacteria, the antibiotic resistance rates to ticarcillin/ clavulanic acid, amikacin, ciprofloxacin, levofloxacin and tienam were still low. ③The recovery rate was 88.9%, 75%, and 73% in Gram-positive, Gram-negative, and microbial-negative peritonitis patients, respectively. Peritoneal dialysis discontinued in fungal peritonitis patients. Conclusion Pathogens and their antimicrobial susceptibilities have changed greatly in peritoneal dialysis-related peritonitis. We should make efforts to improve the positive rate of dialysate culture and the recovery rate of peritonitis patients.

Key words: Peritonitis, Peritoneal dialysis, Drug resistance