Abstract: 【Abstract】 Object To evaluate the accuracy of direct segmental multi-frequency bioimpedance analysis (DSM-BIA) method for estimation of body volume status changes during hemodialysis in maintenance hemodialysis patients. Methods Total body water were measured using each of DSM-BIA (TBW_DSM-pre、TBW_DSM-post) method and body composition spectroscopy equations (BCSE) method according to the whole body wrist -ankle protocol (TBWBCSE-pre、TBWBCSE-post) before and after the same hemodialysis session. The change of TBW detected using each of these two methods was compared to actual ultrafiltration volume(AUV) that was calculated as weight loss during hemodialysis session. Results DSM-BIA method detected TBW change (⊿TBW_DSM:TBW_DSM-pre-TBW_DSM-post)was significantly different from AUV(2.32±1.1 vs 2.65±1.04,t=2.962,P＜0.01), but ⊿STBWDSM has a better agreement with AUV than ⊿TBW_BCSE (-0.3±1.4 L vs -0.65±1.65 L). Conclusions DSM-BIA provides a more accurate estimate of AUV during HD in maintenance hemodialysis patients than BCSE.

Key words: direct segmental multi-frequency bioimpedance analysis, whole body wrist-ankle protocol, body composition spectroscopy equations, body fluid volume