Abstract: 【Abstract】Objective To investigate the effects of intradialytic exercise on inflammation, oxidative stress and endothelial function in maintenance hemodialysis (MHD) patients. Methods Forty patients undergoing MHD for more than 6 months in Tongji Hospital Affiliated to Tongji University from March 2015 to March 2016 were enrolled in this study. They were randomly divided into experimental group in which patients did intradialytic exercise (n=20) and control group (n=20). Clinical data and biochemical results including hemoglobin, high sensitive c- reactive protein (hsCRP), serum albumin, urea clearance index (Kt/V), serum calcium and phosphorus and parathyroid hormone (PTH) were recruited. Blood samples were collected before and after the intervention for the assay of interleukin-6 (IL-6), oxidized low density lipoprotein (ox-LDL), serum soluble intercellular adhesion molecule (sICAM) and serum soluble vascular cell adhesion molecule (sVCAM) by ELISA. Results After the intervention for 24 weeks, there were no significant differences in hemoglobin, serum albumin, urea clearance index Kt/V, IL-6 and oxLDL before and after the intervention in the experimental group (t=- 0.110, - 1.396, - 0.889, - 0.229 and 0.385 respectively; P=0.913, 0.171, 0.380, 0.820 and 0.702 respectively); but there were statistical differences in serum phosphorus, hsCRP, sICAM and sVCAM before and after the intervention in the experimental group (t=2.039, 2.219, 2.309 and 2.211 respectively; P=0.048, 0.033, 0.026 and 0.033 respectively). There were also statistical differences in serum Kt/V, hsCRP, sICAM and sVCAM after the intervention between the experimental group and control group (t =3.706,  -3.144, -2.570 and -3.272 respectively; P=0.001, 0.003, 0.014 and 0.002 respectively). Conclusion Intradialytic exercise can improve inflammation and endothelial function but has no definite effect on oxidative stress in MHD patients.

Key words: Hemodialysis, Exercise, Inflammation, Oxidative stress, Endothelial function