Abstract: 【Abstract】Objective To investigate the relationship between platelet/lymphocyte ratio (PLR) and inflammation status in patients on continuous ambulatory peritoneal dialysis (CAPD) in order to explore a new biomarker for the inflammation status of CAPD patients. Methods A total of 70 CAPD patients treated in the First People's Hospital of Changzhou and 35 healthy individuals as the controls were enrolled in this study. PLR and other laboratory parameters were compared between CAPD patients and controls. CAPD patients were further divided into two subgroups according to the mean value of PLR. Neutrophil/lymphocyte ratio (NLR), high sensitive C- reactive protein (hs- CRP) and other parameters were compared between the two CAPD patient subgroups. The relationship between PLR and NLR, albumin and hs-CRP was assessed using Spearman correlation. Results Neutrophil (t=-3.709, P＜0.001), urea nitrogen (t=-19.858, P＜0.001), creatinine (t=-27.883, P＜0.001), triacylglycerol (t=-5.929, P＜0.001), PLR (t=-4.320, P＜0.001), NLR (t=-10.224, P＜0.001) and hs-CRP (t=- 9.478, P＜0.001) were significantly higher in CAPD patients than in controls. Lymphocyte (t=9.369, P＜0.001), platelet (t=5.263, P＜0.001), hemoglobin (t=15.108, P＜0.001), albumin (t=11.231, P＜0.001) and high density lipoprotein cholesterol (t=7.164, P＜0.001) were significantly lower in CAPD patients than in controls. The mean value of PLR was 136 in CAPD patients. Neutrophil (t=2.155, P=0.035) and lymphocyte (t=4.434, P＜0.001) count were significantly lower in CAPD patients with PLR ≥136 than in those with PLR＜136. Platelet count (t=-4.408, P＜0.001), NLR (t=-2.707, P=0.009) and hs-CRP (t=-2.948, P=0.005) were significantly higher in the CAPD patients with PLR ≥136 than in those with PLR＜136 (P<0.05). PLR was negatively correlated with hemoglobin (r=- 0.307, P=0.001), lymphocyte count (r=-0.588, P＜0.001) and albumin (r=-0.246, P＜0.012), and positively correlated with platelet count (r=0.281,P=0.004), urea nitrogen (r=0.278, P=0.004), creatinine (r=0.196, P= 0.045), hs-CRP (r=0.354, P＜0.001) and NLR (r=0.460, P＜0.001) in CAPD patients. Conclusion PLR can be used as a new biomarker of inflammation status in CAPD patients.

Key words: Continuous ambulatory peritoneal dialysis, Platelet to lymphocyte ratio, Neutrophil to lymphocyte ratio, Inflammation