【Abstract】Continuous renal replacement therapy (CRRT) technology began in the 1960s and has undergone continuous innovation from then on. The therapy mode has changed from continuous arterio-venous hemofiltration to veno-venous hemofiltration that becomes more safe and efficient. The therapeutic indication of CRRT has expanded from renal failure to multi-organ functional failure, suggesting that it also plays an important role in critical care medicine. Currently, it is widely used in emergency department. CRRT combined with extracorporeal membrane oxygenation is effective for patients with severe acute respiratory distress syndrome. However, the large-scale and randomized controlled studies on CRRT and the development of CRRTrelated technology and products are yet insufficient in China. The effects of different membrane materials, the appropriate time for CRRT, and the individualized therapy for patients are expected to be developed in the nearly future.