Abstract: 【Abstract】Objective To explore the effect of gratitude extension-construction theory therapy on adverse mood and self-management in patients with peritoneal dialysis (PD). Methods A total of 108 PD patients in our center were randomly divided into a study group and a control group. Both groups of patients received the same standard treatment regimens, dietary guidance, and routine activity guidance recommendations. The groups were randomly matched; the control group used the traditional missionary model, and the study group added gratitude extension-construction theory therapy based on the traditional missionary model. The anxiety scale, depression scale, gratitude questionnaire (GQ-6) and self-management behavior scale for PD patients were used at 0-12 months after check-in. Results There were no significant differences in Self-rating Anxiety
Scale(SAS) scores(t=-0.742, P=0.518) and Self-rating Depression Scale(SDS) scores (t=-0.862, P=0.721) in the control and study groups before enrollment. The SAS scores (t=- 1.792, P=0.042; t=- 2.852, P=0.029; t=- 3.221,P＜0.01) and SDS scores (t=- 1.781,P=0.046;t=- 2.921, P=0.012;t=- 3.111, P=0.007) in the study group were significantly lower than those in the control group 3, 6 and 12 months after enrollment. The GQ-6 scores of the study group were significantly higher than those of the control group after admission (t=-1.981, P=0.021; t=- 3.321, P=0.007; t=- 4.011, P=0.001). After enrollment for 12 months, the SMSPD scores of fluid change nursing (t=2.962,P=0.004), exit nursing (t=2.835,P=0.006), catheter nursing (t=2.813, P=0.007), taking antihypertensive drugs as prescribed by the doctor (t=2.549,P=0.040), taking phosphate-reducing drugs as prescribed by the doctor (t=2.922,P=0.005), protein intake(t=2.853,P=0.007), body weight (t=3.116,P=0.003),
ultrafiltration volume(t=2.911,P=0.005), and complications (t=2.647, P=0.022) in the study group were higher than those in the control group. Conclusion Gratitude extension-construction theory therapy can improve the adverse mood and the self-management ability of PD patients, which has certain clinical significance and practical significance.

Key words: Gratitude strategy, Peritoneal dialysis patient, Adverse mood, Self-management