Abstract: 【Abstract】Objective To investigate the relationship between Providone-iodine minicap and peritonitis through the etiology and clinical course analyses of the 3 cases with perioperative peritoneal dialysis (PD) associated peritonitis. Methods The etiology of perioperative peritonitis was scrutinized. To analyze the relationship between the brand A of Povidone-iodine minicap and peritonitis, we compared the antibacterial effects of different brands of Povidone-iodine minicaps using in vitro bacterial inhibition tests, and investigated the incidence, clinical characteristics and prognosis of peritonitis in patients treated with different brands of
Povidone-iodine minicaps in this Peritoneal Dialysis Center. Results The possibilities of contamination during the operation of surgery operation and PD manipulation leading to the peritonitis were excluded in the 3 cases with perioperative PD associated peritonitis; the relationship between Povidone-iodine minicap and peritonitis was then suspected. In vitro bacterial inhibition tests found that the antibacterial effect of brand A was weaker than brands B and C. The peritonitis recovered after change of the Povidone-iodine minicap brand A to that of brand B. The incidence of peritonitis was higher in the patients using Povidone- iodine minicap brand A than those using that of brand B in the 89 PD patients (c2=20.578, P<0.001). The clinical peritonitis characteristics of Povidone-iodine minicap associated peritonitis were mild symptoms, negative bacterial culture of the peritoneal exudate, and poor effect of conventional antibacterial infection treatment, without other etiological factors. Conclusion It is necessary to pay attention to the abnormal quality of peritoneal dialysis products as the possible cause of peritonitis when the common causes for peritonitis have been excluded.

Key words: Peritoneal dialysis, Peritonitis, Bacterial culture, Povidone-iodine minicap