Abstract: 【Abstract】Objective To evaluate the value of 99Tcm-MIBI SPECT/CT dual-phase tomography in rEoperation therapy of secondary hyperparathyroidism. Methods A total of 19 patients with secondary hyperparathyroidism who underwent rEoperation from Jan. 2016 to Mar. 2019 were retrospectively analyzed. All patients underwent 99Tcm-MIBI SPECT/CT dual- phase tomography before rEoperation, and the results were compared with those of neck ultrasonography. The diagnostic efficacy of 99Tcm-MIBI SPECT/CT dualphase tomography and ultrasonography for parathyroid lesions was compared with the "golden standard", pathological findings of the surgical samples. Results The sensitivities of 99Tcm-MIBI SPECT/CT dualphase tomography and neck ultrasonography were 95.2% and 52.3% respectively for the diagnosis of secondary hyperparathyroidism (P=0.004) and were 90.9% and 18.2% respectively for the diagnosis of ectopic parathyroid gland (P=0.008). The accuracies of 99Tcm-MIBI SPECT/CT dual-phase tomography in the diagnosis of secondary hyperparathyroidism and ectopic parathyroid gland were 71.4% and 83.3%respectively, higher than those of neck ultrasonography (34.3% and 18.2% respectively). Conclusions 99Tcm-MIBI SPECT/CT dual-phase tomography is more sensitive than ultrasonography in detection of parathyroids, especially in detection of ectopic parathyroids, in rEoperation therapy of secondary hyperparathyroidism. This method is clinically valuable for the localization of parathyroids in secondary hyperparathyroidism patients before rEoperation.

Key words: Secondary hyperparathyroidism, Single photon emission computed tomography, Parathyroidectomy, Intact parathyroid hormone