Abstract: 【Abstract】Objective To investigate the application effect of grade I quality control in the homogeneous management of large blood purification centers in tertiary hospitals. Methods A grade I quality control management network of the blood purification center was established in April 2018, and all nurses participated in quality control and feedback in time for renovation. Satisfaction from patients in one year (March 2018 to April 2019) was compared before and after grade I quality control management. The average knowledge and operation scores were compared between groups before and after grade I quality control management
in certificated hemodialysis nurses working less than 3 years and those working more than 3 years. Results Satisfaction from patients increased significantly after grade Ⅰ quality control management (χ2=5.065, P=0.024). The average knowledge and operation scores improved significantly after one year of grade I quality control management in the two groups of nurses (t=4.271 and 2.430, P=0.002 and 0.025). The average scores were different between the two groups before grade I quality control management (t=5.347, P=0.001) and became no differences after grade I quality control management for one year (t=0.547,
P= 0.589). Conclusion The application of grade I quality control in homogeneous management of blood purification centers improved the knowledge and operation levels of nurses, especially nurses with less experiences. Eventually, satisfaction from patients increased and patients benefited from homogeneous and standardized nursing services.

Key words: Quality control, Hemodialysis, Quality of care, Homogenization