Abstract: 【Abstract】Anemia is a common complication of peritoneal dialysis (PD) patients. The compliance rate of anemia treatment is still lower in China. The mechanisms of anemia in PD patients include the deficiency of erythropoietin (EPO) production and lower EPO response due to abnormal oxygen sensing pathway, iron deficiency, inflammation, malnutrition and many others. In addition to maintain hemoglobin within the target range, to reduce hemoglobin variation is also essential in the treatment of anemia in PD patients. Hemoglobin variation is a clinical phenomenon affected by many factors including drug related factors, patient related factors, inflammation, iron deficiency, infection and many others. Hemoglobin variation and its related management must be concerned during the treatment of anemia in PD patients to improve their prognosis.

Key words: Peritoneal dialysis, Anemia, Hemoglobin variation