Abstract: 【Abstract】Objective To explore the independent influencing factors for interdialytic blood pressure variability (BPV) in adult maintenance hemodialysis (MHD) patients. Methods A total of 505 adult MHD patients treated in Handan Central Hospital between Jan 2015 and Sept 2019 were retrospectively analyzed. The coefficient of interdialytic systolic blood pressure (SBP) variation was calculated from the standard deviation of SBP / average SBP value x 100%. According to the interquartile values (120, 130, 140 and 150) of the coefficient of interdialytic SBP variation, the patients were divided into 4 groups: low coefficient of variation
group (n=127), medium coefficient of variation group (n=126), high coefficient of variation group (n=126), and extremely high coefficient of variation group (n=126). Clinical data, laboratory indicators and use of drugs were compared among the 4 groups. Logistic regression model was used to analyze the independent influencing factors for the coefficient of interdialytic SBP variation. Results In medium coefficient of variation group, dialysis time was less than the other 3 groups (t=3.556, 3.674 and 4.403 respectively; P=0.024, 0.028 and 0.018 respectively). In low coefficient of variation group, patients with type 2 diabetes were more than those in the other 3 groups (χ2=5.567, 5.567 and 4.764 respectively; P=0.027, 0.031 and 0.020 respectively), and ultrafiltration volume was higher than that in the other 3 groups (t=3.653, 3.528 and 4.039 respectively; P=0.027, 0.031 and 0.020 respectively). In low coefficient of variation group, interdialytic body weight gain was less than that in the other 3 groups (t=3.525, 3.611 and 3.334 respectively; P=0.037, 0.039 and 0.044 respectively). In high coefficient of variation group, serum calcium was higher than that in the other 3 groups (t=3.346, 3.211 and 3.509 respectively; P=0.031, 0.036 and 0.030 respectively). In extremely high coefficient of variation group, patients using calcium channel blockers were less than those in the other 2 groups (χ2=5.534 and 6.588; P=0.012 and 0.010). Logistic regression analysis showed that the higher interdialytic body weight gain was the independent risk factor for coefficient of interdialytic SBP variation, and that the increase of ultrafiltration
volume and the use of calcium channel blockers were the independent protective factors for coefficient of interdialytic SBP variation. Conclusion The size of interdialytic body weight gain, the ultrafiltration volume, and the use of calcium channel blockers were independently correlated with the interdialytic BPV in adult MHD patients.

Key words: Adult, Maintenance hemodialysis, Blood pressure variability, Influencing factor