Abstract: 【Abstract】Objective To investigate the incidence and risk factors of psychological (anxiety and depression) and cognitive dysfunctions in patients undergoing maintenance hemodialysis (MHD). Methods Cognitive Emotion Regulation Questionnaire (CERQ), Center for Epidemiologic Studies Depression (CES- D) Scale, and Hospital Anxiety and Depression (HAD) Scale were used in this study. Results A total of 309 MHD patients completed the investigation. The median score of CERQ was 96.25 (86.21, 108.32). The CESD survey showed no depressive state in 181 cases (58.58%), possible depression state in 121 cases (39.48%),
and 6 cases (1.94%) requiring psychological intervention. The prevalence of anxiety was 96.77% by using HAD scale. The rates of mild, moderate and severe anxiety were 35.60%, 50.49% and 10.68%, respectively. Multivariate linear regression analysis suggested that CES-D score was positively correlated with the use of catheter for hemodialysis (β=0.153, P=0.015) and negatively correlated with serum albumin level (β=-0.141, P=0.003). HAD score was positively correlated with dialysis frequency (β=0.145, P=0.022) and negatively correlated with albumin level (β=-0.146, P=0.002). Both CES-D score and HAD score were positively correlated with CERQ score (r=0.314 and 0.143; P=0.001 and 0.012). Conclusions MHD patients presented higher incidences of psychological and cognitive dysfunctions. Cognitive dysfunction increased the incidences of anxiety status and depression. Nutritional status was closely related to the psychological state in MHD patients.

Key words: Maintaining hemodialysis, Cognitive function, Anxiety state, Depression state, Influence factor