Abstract: 【Abstract】Objective To assess the differences about the situation and related factors of coronary artery calcification (CAC) in patients with peritoneal dialysis (PD) and those with hemodialysis (HD). Methods According to age and gender balance, 38 PD patients and 38 HD patients with dialysis age of more than one year were recruited in this study. CAC score was calculated after spiral CT examination. Clinical characteristics, related factors and the differences between PD patients and HD patients were analyzed based on the severity of CAC. Results The prevalence of CAC was similar between the two groups. However, CAC score
was significantly lower in PD patients than in HD patients (P=0.003). In PD patients, those with severe CAC had higher rates of cerebrovascular disease (P=0.000) and/or diabetes (P=0.012); those with mild CAC had higher rates of taking vitamin D (P= 0.000) and calcium preparations (P=0.000), and higher levels of low density lipoprotein cholesterol (P=0.000) and total cholesterol (P=0.010). The severity of CAC was negatively correlated with diastolic blood pressure (P=0.000), and positively correlated with dialysate glucose load (P=0.040) and the prevalence of abdominal aortic calcification (P=0.000). Multivariate linear regression showed that CAC score was positively correlated with BMI (P=0.030) and negatively correlated with diastolic blood pressure (P=0.018). In HD patients, the severity of CAC was positively correlated with age (P=0.005) and the prevalence of abdominal aortic calcification (P=0.009). Multivariate linear regression showed that CAC score was positively correlated with BMI (P=0.001), serum calcium (P=0.027) and the prevalence of abdominal aorta calcification (P=0.020). Conclusion Clinical characteristics and risk factors of CAC were different between PD patients and HD patients. Therefore, individualized management is required between the two groups of patients.

Key words: Peritoneal dialysis, Hemodialysis, Coronary artery calcification