Abstract: 【Abstract】Objective To compare the clinical characteristics of pulmonary tuberculosis in maintenance hemodialysis (MHD) patients and in general population. Methods A total of 78 MHD patients complicated with pulmonary tuberculosis admitted to The Sixth People's Hospital of Zhengzhou from January 2017 to May 2019 were retrospectively reviewed as the observation group; a total of 110 pulmonary tuberculosis patients admitted to this hospital in the same period were recruited as the control group. Clinical data were compared between the two groups. Results The clinical symptoms of cough and expectoration (χ2=0.282, P=
0.595), fever (χ2=1.709, P=0.091), night sweating (χ2=1.489, P=0.222), hemoptysis (χ2=0.656, P=0.418), chest stuffy and chest pain (χ2=1.472, P=0.232) and fatigue (χ2=1.374, P=0.241) were similar between the two groups of patients. The laboratory tests of positive tuberculosis antibody rate (χ2=3.910, P=0.048), positive TSPORT rate (χ2=4.034, P=0.045), erythrocyte sedimentation rate (χ2=5.691, P=0.017), rate of acid-fast bacilli in sputum smear (χ2=3.910, P=0.048) and lesion ≥3 lobes (χ2=4.201, P=0.040) were statistically significant between the two groups of patients. The effectiveness of anti- tuberculosis drugs was similar between the two groups of patients (χ2=0.180, P=0.671); however, the adverse reactions of nausea and vomiting (χ2=6.732, P=0.009), blurred vision (χ2=5.930, P=0.015), sleep disturbance (χ2=5.495, P=0.019), finger numbness (χ2=5.585, P=0.018) and liver function impairment (χ2=4.427,P=0.035) were different between the two groups of patients. Conclusion The clinical characteristics and the effectiveness of anti-tuberculosis drugs were similar in MHD patients complicated with pulmonary tuberculosis and in pulmonary tuberculosis patients in general population. However, the rates of adverse reactions to anti-tuberculosis drugs were higher and the hospitalization period was longer in MHD patients with pulmonary tuberculosis.

Key words: Maintenance hemodialysis, Pulmonary tuberculosis, Clinical feature, Adverse reaction