Abstract: 【Abstract】End-stage renal disease (ESRD) is a global healthcare burden. Hemodiafiltration (HDF)is capable of effective clearance of solutes of low and middle molecular weight by combining diffusion and convection. With the improvement of dialyzer membrane and the progress of ultrafiltration control system and water treatment techniques, HDF is currently an accessible, safe and well- established treatment option. Latest clinical evidence demonstrated that HDF can reduce mortality of ESRD patients by superior solutes clearance and/or cooling effect.

Key words: Hemodialysis, Hemodiafiltration, End-stage renal disease