Abstract: 【Abstract】Objective To systematically review the removal effect of blood lactic acid by blood purification (BP) versus by conventional treatment in the patients with lactic acidosis. Methods The databases of Web of science, PubMed, CNKI, WanFang, VIP and CBMDisc were retrieved from the establishment of the database to January 2020 for the randomized controlled trials of lactic acidosis treatment by BP and conventional methods. The control group used conventional treatment, and the trial group used BP on the basis of conventional treatment. The software of STATA12.0 was used for meta analysis. The continuous variables
were expressed as SMD and 95% CI. Funnel plot was used to evaluate the publication bias. Results There were totally 10 randomized controlled trials including 296 cases in trial group and 267 cases in control group. Meta- analysis showed that the reduction of lactate levels after the treatment for 12, 24 and 48 hours were more in trial group than in control group, and the differences were significant (12h: SMD＝-1.14, 95% CI＝-2.15～-0.13, P=0.027; 24h: SMD＝-2.06, 95% CI＝-3.09～-1.02, P=0.000; 48h: SMD＝-2.60, 95% CI＝-4.00～-1.19, P=0.000). Conclusion Both BP and conventional treatment removed blood lactic acid effectively in lactic acidosis patients, but the curative effect using BP was better. These results have therapeutic implications in clinical practice.

Key words: Blood purification, Lactic acidosis, Lactate, Meta-analysis