Abstract: 【Abstract】Objective To investigate the relationship between serum fibroblast growth factor-23 (FGF-23) level and radial artery calcification (RAC) and arteriovenous fistula (AVF) dysfunction in hemodialysis patients. Methods This prospective study included 212 maintenance hemodialysis (MHD) patients undergoing AVF surgery. Serum FGF-23 level was measured by ELISA. Clinical and biochemical data were collected. RAC was assayed by hematoxylin- eosin staining. Serum FGF- 23 levels were compared between patient groups, and the prediction effect of serum FGF- 23 level was then evaluated. Results The prevalence of RAC was 57.8% (123/212) in the MHD patients. When the cut-off value of serum FGF-23 level was set at 488.5 ng/ml, the sensitivity and specificity for the diagnosis of RAC were 0.797 and 0.921 respectively. When the cut-off value of serum FGF-23 level was set at 490.9 ng/ml, the sensitivity and specificity for the diagnosis of AVF dysfunction were 0.757 and 0.560 respectively. Conclusion Higher prevalence of RAC was found in end-stage renal disease patients. Serum FGF-23 appears to be a sensitive and specific marker of RAC and AVF dysfunction in hemodialysis patients.

Key words: Hemodialysis, Radial artery calcification, Arteriovenous fistula, Fibroblast growth factor-23