Abstract: 【Abstract】Objective To investigate the protein-energy wasting (PEW) status and its correlation with appetite in chronic kidney disease (CKD) patients treated with maintenance dialysis, so as to provide scientific basis for clinical nutrition intervention and management. Methods This study is a cross-sectional study, recruiting participants from three hospitals through a convenient sampling method. The malnutrition inflammation scale and appetite visualization scale were used to investigate the PEW and appetite status. Body composition monitoring, anthropometrics and biochemical examinations were performed to assess patients' nutrition and body composition. Multivariate logistic regression was used to explore the relationship between PEW and appetite. Results A total of 101 maintenance dialysis patients were recruited, and the incidence of PEW was 31.7%. In PEW group, the five dimensions of appetite, the mean score for desire to eat and the amount of food consumed were relatively lower, being 39.41± 26.25 and 31.63±25.67. The satiety score in PEW group was significantly higher than that in non-PEW group (Z=3.136, P=0.002). In addition, the ratio of gastrointestinal symptoms was significantly higher in PEW group (75.0%) than in non-PEW group (43.5%). Multiple logistic regression analysis showed that gastrointestinal symptoms (OR=4.445, P=0.005) and postprandial satiety (OR= 1.023, P=0.012) were the risk factors for PEW. Conclusion Nearly one third of maintenance dialysis patients have PEW. The higher postprandial satiety and higher ratio of gastrointestinal symptoms are the risk factors for PEW.

Key words: Chronic kidney disease, Protein-energy wasting, Appetite, Satiety, Gastrointestinal symptom