Abstract: Objective  To observe 25-hydroxyvitamin D [25(OH)D] evel and abdominal aortic calcification (AAC) in dialysis patients, and to investigate the relationship between 25(OH)D level and vascular calcification (VC).  Methods   We enrolled 100 dialysis patients from Cangzhou Central Hospital in this study. Their clinical laboratory data were collected. Abdominal lateral radiographic image was performed to evaluate AAC and to calculate AAC score (AACs). Spearman correlation analysis was used to analyze the relationship between 25(OH)D level and AACs. Logistic regression was used to analyze the risk factors for AAC. Receiver operating curve (ROC) was used to evaluate the accuracy of 25(OH)D level for the prediction of AAC.  Results   Among the 100 dialysis patients, the incidence of vitamin D deficiency was 61% and the incidence of AAC was 72%. 25(OH)D level was negatively correlated with the degree of AAC (r=-0.605, P＜0.001). Logistic regression showed that age (OR=1.067, 95% CI: 1.025～1.207, P=0.013), 25(OH)D level (OR=0.889, 95% CI: 0.819～0.971, P=0.011) and dialysis modality (OR=0.977, 95% CI: 0.802～0.964, P=0.038) were the independent influence factors for the occurrence of AAC. ROC showed that when the cut-off value of 25(OH)D level for the prediction of AAC was set at 13.8ng/ml, the curve under the area was 0.721(95% CI: 0.589～0.853, P=0.001), with the sensitivity of 63.9%, the specificity of 60.7%, and Yoden index of 0.246.  Conclusion   25(OH)D level is negatively correlated with VC in dialysis patients. Low 25(OH)D level is one of the independent risk factors for VC. Monitoring 25(OH)D level in dialysis patients may be useful for the prediction of VC risk.

Key words: Vascular calcification; , 25(OH)D; , Abdominal aortic calcification; , Dialysis