Abstract: Objective  The purpose of this study was to find out the independent factors influencing the increase of peritoneal solute transport rate (PSTR) in peritoneal dialysis (PD) patients by retrospective analysis.  Methods  The PD patients were the adults (≥18 years old) with end-stage renal disease who had undergone PD in Peking University People's Hospital and had subjected to two peritoneal balance tests from June 2017 to June 2022. According to the changes of PSTR, the patients were divided into two groups: PSTR ascending group and PSTR descending group. Independent sample T test, rank sum test or chi square test was used to compare the differences in demographic data, dialysis program, medication and laboratory indicators between the two groups. Logistic regression (input method) was used to detect the independent risk factors relating to the increase of PSTR.  Results  This study enrolled a total of 80 PD patients, of which 48 (60%) were in the PSTR ascending group and 32 (40%) in the PSTR descending group. The PSTR ascending group had the characteristics of longer dialysis age (Z=-2.642, P=0.008), lower baseline PSTR (t=-3.215, P=0.002), and higher proportion of patients using continuous PD (χ2=3.879, P=0.049), as compared those in the PSTR descending group. Logistic regression showed that dialysis age (OR=0.975, 95% CI 0.959~0.991, P=0.002) and baseline PSTR (OR=21 455.039, 95% CI 43.218~10 651 164.480, P=0.002) had the independent effects on the increase of PSTR, and that whether continuous PD was used or not (OR=2.442, 95% CI 0.734~8.130, P=0.146) was not an independent risk factor for the increase of PSTR.  Conclusion  Patients with longer dialysis age, lower baseline PSTR and continuous PD mode are more likely to have increased PSTR. However, continuous PD mode is not an independent risk factor for the increase of PSTR.

Key words: Peritoneal solute transport rate, Dialysis age, Continuous peritoneal dialysis, Intermittent peritoneal dialysis