Abstract: Objective  To investigate the effect of HA resin haemoperfusion (HP) + haemodialysis (HD) on inflammatory-nutritional status and adverse cardiovascular events in patients with secondary hyperparathyroidism (SHPT).  Methods   800 patients with SHPT from June 2021 to June 2022 were selected for the prospective study and grouped by random number table method, 400 patients in each group. The control group was treated with conventional haemodialysis (HD) 3 times a week and the observation group was treated with conventional HD+HP 3 times a week. The clinical efficacy and small molecular indicators [blood phosphorus, serum calcium, alkaline phosphatase (ALP)], medium and large molecular indicators [intact parathyroid hormone (iPTH), β2-microglobulin (β2- MG), cystatin C (CysC)], nutritional status [serum albumin (ALB), prealbumin (PA), transferrin (TRF)], inflammation level [interleukin-1 (IL-1), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6)] and cardiovascular events.  Results  The total effective rate of the observation group was 93.25% higher than that of the control group 77.25% (χ2=40.718, P=0.000); there was no significant difference between the two groups in terms of ALP, blood phosphorus and blood calcium levels after treatment (t=1.017, 1.305, 0.603, P=0.309, 0.192, 0.547);After treatment, the levels of iPTH, CysC, and β2-MG were lower in the observation group than in the control group, and the levels of ALB, PA, and TRF were higher than in the control group (t=42.160, 21.114, 20.480, 28.321, 33.596, 37.387, all P＜0.001); compared with the control group after treatment, the levels of IL-6, CRP, TNF-α, and IL-1 levels were lower in the observation group compared to the control group after treatment (t=17.164, 16.131, 8.024, 21.639, all P＜0.001); The incidence of cardiovascular events was lower in the observation group at 4.75% than in the control group at 10.50% (χ2=9.388, P=0.002). Conclusion HP combined with HD treatment can improve the scavenging effect of small molecules, macromolecules and other toxic substances, maintain the nutritional and metabolic balance of the body, improve the state of excessive inflammatory response, and reduce the occurrence of cardiovascular events, thereby improving the therapeutic effect, which is worthy of clinical promotion.

Key words: Resin, Hemoperfusion, Maintenance hemodialysis, Secondary hyperparathyroidism