Abstract: Objectives  To analyze the correlation between calciprotein particles (CPPs) and coronary calcification in chronic kidney disease (CKD) G3～5D patients, and to discuss the predictive value and influencing factors of CPPs for coronary calcification in both hemodialysis (HD) and non-HD patients.  Method This single-centered and cross-sectional survey study enrolled 75 CKD G3～5D patients. Based on CKD stage and coronary artery calcification score (CACS), the patients were divided into calcification group and non-calcification group to compare the differences of CPPs at different CKD stages between the two groups. The risk and protective factors for calcification in CKD G3～5 (non-dialysis) patients were assessed using bivariate logistic regression. The correlation between CPPs and degrees of coronary calcification in HD patients was evaluated using Kruskal-Wallis test and Pearson chi square test. The influencing factors for CPPs in CKD G3～5D patients with calcification were investigated using univariate linear regression.  Result  For CKD G3～5 (non-dialysis) patients, bivariate logistic regression showed that CPPs (increased per SD) were the independent protective factors for coronary calcification; an increase of one SD (10.20) of CPPs was associated with a 73.4% reduction in coronary calcification risk (OR: 0.266, 95% CI: 0.077～0.916, P=0.036). Kruskal-Wallis test showed that CPPs increased with the increase of CACS (H=6.557, P=0.037), and CACS increased with the increase of CPPs (H=7.440, P=0.024). Pearson chi square test demonstrated that the proportion of HD patients with CACS >100 was more in the middle and high CPPs groups than that in the low CPPs group, and the ratios of calcification degrees were statistically different among the 3 CPPs groups (χ2=9.800， P=0.044). Univariate linear regression showed a negative correlation between CPPs and eGFR-EPI (β=-0.424,  P=0.004) and positive correlations between CPPs and serum levels of Scr (β=0.453, P＜0.001) and calcium (β=0.328, P=0.014) in CKD G3～5D patients with coronary calcification.  Conclusion  In CKD G3～5 (non-dialysis) patients, CPPs are the protective factors for coronary calcification. In contrast in HD patients, higher CPPs implies severer coronary calcification. Serum levels of eGFR-EPI, Scr and calcium are the potential factors for CPPs changes in CKD G3～5D patients with coronary calcification.

Key words: Calciprotein particles, Chronic kidney disease, Coronary calcification