Abstract: Objective T o analyze the current research status of eye lesions in patients with end-stage renal disease, and to explore the hotspots and frontiers of research.  Method  CiteSpace literature analysis software was used to analyze, summarize, and generalize the relevant literature published in the Web of Science database in the past 20 years.  Result  A total of 307 relevant literature were included, and the number of publications on eye lesions in patients with end-stage renal disease is slowly increasing. The research hotspots include the study of eye symptoms, the pathological and physiological mechanisms of eye lesions in end-stage renal disease, and the management of dialysis patients. The research frontier mainly focuses on the impact of hemodialysis treatment on patients' eye lesions.  Conclusion  The overall research on eye lesions in patients with end-stage renal disease is in a slow upward development stage. Researchers in the fields of nephrology and ophthalmology can broaden their research ideas, actively explore from multiple perspectives, and provide high-quality evidence support for the development and clinical practice of eye lesions in patients with end-stage renal disease.

Key words: End-stage renal disease, Hemodialysis, Ophthalmology