Abstract: Objective To observe changes of serum adrenomedullin (ADM) in acute renal failure (ARF) patients and its correlation to serum creatinine, C-reactive protein, IL-6 and TNF- . Methods Seventy-six cases of simple ARF treated in the Second Hospital of Shanxi Medical University and without having acute or chronic infection, malignancy, multiple organ failure, blood transfusion and glucocorticoid and immunosuppressant therapy were enrolled in this study. Twenty-five healthy individuals were used as the controls. Serum ADM, C-reactive protein, IL-6 and TNF- were determined by ELISA Results Serum ADM, C-reactive protein, IL-6, TNF- and creatinine were significantly high in the patients (P＜0.001, as compared with those of controls). The higher serum ADM was positively correlated with serum C-reactive protein, IL-6，TNF- , and creatinine (p<0.001). Conclusions Higher serum ADM was found in ARF patients and the higher serum ADM was positively correlated with serum creatinine and the inflammatory factors. In ARF patients, ADM may be involved in the inflammatory processes and renal function improvement.

Key words: Acute renal failure