Abstract: Objective To observe the levels of plasma and urinary urotensin Ⅱ (UⅡ) in the chronic renal failure patients (CRF) and the influence of hemodialysis, continuous ambulance peritoneal dialysis(CAPD) and allograft renal transplantation on UⅡ levels respectively. Methods Controlled with normal subjects, the plasma and urinary UⅡ levels were examined by radioimmunoassay method in a population of 72 CRF patients who received non-dialysis (ND group), maintenance hemodialysis (HD group), continuous ambulatory peritoneal dialysis (PD group) or allograft renal transplantation (KT group) respectively. Results The plasma UⅡ levels increased significantly in all patients (P ＜0.0001)，Which in HD group was the highest,ND group the second, then PD group and KT group was the lowest. The urinary UⅡ excretion decreased in ND group、HD group、PD group obviously (P ＜0.05），but increased singnificantly in KT group(P ＜0.01)；Conclusions The investigation proved that a higher level of plasma urotensin Ⅱ and a lower urinary UⅡ excretion exist in the patients with chronic renal failure, and these changes become even more obvious in the patients who received hemodialysis or peritoneal dialysis. Allograft renal transplantation can reduce the increased levels of plasma UⅡand can increase urinary UⅡ excretion in CRF patients. The research imply that UⅡ may be an important peptide which involved in the pathophysiology of chronic renal failure.

Key words: Chronic renal falure, Hemodialysis, Continuous ambulatery peritoneal dialysis, Allograft kidney transplantation