Abstract: Objective To clarify the mechanism of high levelin hemodialysis patients Lp(a) in hemodialysis patients. Methods The study was conducted on a sample of 53 chronic renal failure patients (males: 37, females: 16, age 23～75 years) who had receired hemodialysis treatment above one year. Fourty-two samples from healthy physical examination were as controls. Lp(a) level were detected by AEROSET-2000 biochemistry auto-analyzer. The quantifications of Ox-LDL, IL-1 beta, IL-6, IL-8 and TNF-alpha were performed with double-antibody ELISA. Results The serum Lp(a) levels were remarkably higher in CRF patients than in the control subjects (P ＜0.05). The serum ox-LDL IL-6 and IL-8, TNF-α levels in hemodialysis patients were remarkably higher than in the control subjects, but there were no significant difference of IL-1β level between the two groups. There were significant correlations between Lp(a) and IL-6、IL-8 and ox-LDL. Conclusions Lp(a) has comelation with inflammation and oxidative stress. It maybe one of the reasons of in creased and disordered Lp(a) level in hemodialysis patients.

Key words: Lipoprotein(a), Ox-LDL, Cytokine