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›› 2006, Vol. 5 ›› Issue (12): 835-838.
• 基础研究 • Previous Articles Next Articles
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Abstract: Objective To investigate the effect of hematocrit (Hct) on urea clearance in hemodialysis through a trial in vitro. Methods After adding quantitative reagent of urea, 3000ml fresh blood of pig was separated to plasma and cells and then mixed up to 8 samples (300ml per sample). The Hct levels of above samples were as follows: 0、10%、20%、30%、40%、50%、60% and 70%. In same hemodialysis conditions, the 8 blood samples were dialysed for 3 minutes in turn. The urea concentration of pre and post hemodialysis and the collected dialysate were measured and urea reduction ratio (URR) was calculated. Results The URR were 97.7%、95.6%、90.5%、85.8%、84.1%、75.9%、62.5% and 54.8% (r=-0.9654) respectively(P<0.01) as the Hct elevated. The amounts of removed urea calculated through the blood urea concentration pre and post dialysis were the same as that of through the urea concentration of collected dialysate. Conclusion The urea clearance was reduced significantly as Hct rises. This study also explored a scientific method to do research on this kind of problems in hemodialysis.
Key words: Hemodialysis, Urea, Clearance
CLC Number:
R318.16
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https://www.cjbp.org.cn/EN/Y2006/V5/I12/835