Abstract: Objective To investigate the clinical characteristics of patients with liver failure in pregnancy and analyze the correlative factors of patients’prognosis. Methods The clinical data of patients suffered from liver failure during pregnant period were analyzed with EXCELL2000, STATA7.0 software and t test. Results Seven of eleven patients occurred in late pregnancy and 6 were subacute liver failure. Three of five patients with HBV infection were dead (one superinfected with HEV); 3 with unidentified diagnosis; another 3 were syphilis, acute fatty liver of pregnant and CMV infection. Among 11 patients the complications occured: low serum albumin(11), ascites (10), hypoglycemia(9) and metabolic disorder(7),hepatic encephalopathy(6 cases, among them 4 patients occurred after ending pregnancy) disseminated intravascular coagulation (DIC)(5), spontaneous bacterial peritonitis(SBP)(4),renal failure(3)and cerebral edema(3). The recovery rate among 6 patients given blood purification therapy was 72.7%, which was higher than that of patients just given internal manipulation(40%). Three of four patients with coma got conscious. Two patients with coma who just received internal therapy didn’t improve at all. Mono-factor analysis showed that the prognosis factors including pregnant period, clinical typing and clinical staging, HBV infection and HBV DNA level, cerebral edema, DIC, prothrombin activities (PTA), the serum total bilirubin (TBil) and therapy with blood purification. Poly-factors analysis showed PTA and TBil were the independent dangerous factors. Conclusions ① HBV infection is still one of the most important causes of liver failure in pregnancy and the prognosis is bad usually. ② Metabolic disorder is probably the main cause inducing the multi-complications in liver failure in pregnancy and affect the prognosis directly. ③Treated with blood purification can correct the body’metabolic disorder in time and it has close relationship with improved recovery rate.

Key words: Liver failure, Pregnancy, Clinical characteristic