Abstract: Objective To study the effects of high glucose and uremic serum on the expression of VEGF in human peritoneal mesothelial cell. Methods Reverse transcription polymerase chain reaction(RT-PCR) and immunohistochemistry were applied to detect the expression of VEGF. Results The increased expression of peritoneal VEGF was found in high glucose and uremic serum groups compared with normal group. Conclusions High glucose or uremic serum upregulates the expression of peritoneal VEGF and may induce the increasement of neoangiogensis, this may cause the incidence of peritoneal ultrafiltration failure.

Key words: Vascular endothelial growth factor, High glucose, Uremic serum