Abstract: Objective  To investigate the efficacy of oXiris-endotoxin adsorption technique in the treatment of end-stage renal disease (ESRD) complicated with sepsis.   Methods  A total of 41 patients with ESRD complicated with sepsis who were hospitalized in the First Affiliated Hospital of Henan University of Science and Technology from January 1, 2021 to July 30, 2023 were enrolled. Among these patients, 22 are in the oXiris filter treatment group, and the other 19 patietns are in the group treated by continuous veno-venous hemofiltration (CVVH) combined with Hemoperfusion (HP). In-hospital mortality, length of stay in ICU, length of mechanical ventilation, length of continuous renal replacement therapy, number of patients with mechanical ventilation, number of filter and Acute Physiology and Chronic Health Evaluation (Apache-II), Norepinephrine (NE) dosage and laboratory test results at the beginning of and after hemopurification treatment were compared between the two groups.  Results  The mechanical ventilation duration in oXiris group was significantly shorter than that in CVVH+HP group (Z= -3.749, P=0.001). After treatment, APACHE-II (t=-4.481,    P=0.001), NE dosage (t=-2.036, P=0.049), C-reactive protein, procalcitonin (Z=-2.850, P=0.004), interleukin-6 (Z=-2.512, P=0.012) in oXiris group were significantly lower than those in CVVH+HP group.  Conclusion  oXiris-endotoxin adsorption technique can effectively reduce inflammatory factors in ESRD patients with sepsis, and it’s effect is better than CVVH+HP treatment; which has good value of clinical application.

Key words: oXiris-endotoxin adsorption, Hemoperfusion, Septic shock, End-stage renal disease