Abstract: Objective  To systematically review the dose-response relationship between dietary potassium intake and risk of mortality, CKD progression in chronic kidney disease patients.  Methods  PubMed, The Cochrane Library, EM-base, Web of Science, CNKI, WanFang Data, VIP and CBM databases were electronically searched to collect studies about dietary potassium intake and risk of mortality, CKD progression in patients with CKD from inception to August 2023. Two reviewers screened literature, extracted data and assessed the quality of included studies independently. Meta-analysis was performed by using R4.2, and the dose-response relationship was analyzed by using restricted cubic spline function and generalized least squares estimation.  Results  A total of 14 studies involving 53694 patients were included. The results of meta-analysis showed that no significant association between potassium intake and mortality in CKD patients (RR=0.875, 95% CI:0.746～1.027, P=0.100). Dose-response meta-analysis showed an L-shaped association between potassium intake and mortality in CKD patients (non-linear test P=0.010), while there was no significant non-linear trend between potassium intake and CKD progression (non-linear test  P=0.226). The linear trend results showed that for every unit increase in potassium intake in CKD patients, the risk of CKD progression was reduced by 21.6% (RR=0.784,95% CI:0.625～0.983, P=0.031).  Conclusion   Current evidence suggests that potassium intake in CKD patients should not be excessively restricted. Due to limited quality and quantity of the included studies, more high-quality studies are needed to verify above conclusion.

Key words: Dietary potassium intake, Mortality, Chronic kidney disease progression, Dose-response relationship