Abstract: Objective To analyze the survival rate and prognostic factors in paraquat intoxication patients treated with hemoperfusion combined with hemodialysis (HP+HD). Methods A total of 67 paraquat intoxication patients treated in this hospital in the period from June 2010 to May 2013 were retrospectively analyzed. They were divided into control group, HP+HD group and enhanced HP+HD group base on the treatment method. Kaplan-Meier analysis was performed for the estimation of survival rate, which was then compared among the three groups by using the log-rank test. Cox regression was used for multivariate analysis. Results The survival rate after the treatment for 30 days was 20.8%, 30.2%, and 37.0% in control group, HP+ HD group and enhanced HP+HD group, respectively. The survival curve was statistically different among the three groups (χ2=6.22, P = 0.04). The RR value was 0.81 (P=0.00) for HP+HD frequency, 1.04 (P=0.01) for paraquat intoxication amount, and 1.19 (P=0.00) for plasma paraquat concentration before treatment. Conclusions The enhanced HP+HD group had the highest survival rate among the three groups. HP+HD frequency, paraquat intoxication amount, and plasma paraquat concentration before treatment were the independent factors affecting prognosis. HP+HD can improve the survival rate in patients with paraquat intoxication.

Key words: Paraquat, Survival rate, Hemoperfusion, Hemodialysis, Cox regression analysis