Abstract: Objective To investigate the effect of pulse high volume hemofiltration (PHVHF) in patients with abdominal infection after gastrointestinal cancer surgery. Methods Forty patients with abdominal infection after gastrointestinal cancer surgery were randomly divided into PHVHF group (n=20) and control group (n=20). Routine therapy was conducted to both groups of patients, with the addition of PHVHF to the patients in PHVHF group. APACHE Ⅱ score, heart rate (HR), mean arterial pressure, blood biochemical parameters (BUN, Cr and K+), oxygenation index (PaO2/FiO2), treatment period in ICU, and mortality within 28 days were assayed before and after the treatment. Results In PHVHF group after the treatment, HR, BUN, Cr, K+ , PaO2/FiO2, and APACHE Ⅱ score improved significantly (P＜0.05). The improvement of BUN, Cr, PaO2/FiO2 and APACHE Ⅱ score was more prominent in PHVHF group than in control group (P＜0.05). Mortality within 28 days was lower in PHVHF group (10.0%±0.8%) than in control group (22.0%±0.7%; t=4.305, P=0.036). Conclusion PHVHF stabilizes hemodynamics and homeostasis, improves oxygenation, and plays a supporting role to multiple organs, thus alleviates disease conditions, and improves prognosis in abdominal infection patients after gastrointestinal cancer surgery.

Key words: Abdominal infection after gastrointestinal cancer surgery, Pulse high volume hemoflitration, Hemodynamics