Abstract: Objective To observe the effect of in-center nocturnal hemodialysis (INHD) on hyperphosphatemia in uremic patients. Methods fifty-six patients who received INHD more than 6 months were investigated. The predialysis serum phosphorus, serum calcium and serum iPTH before and after entering INHD were collected. And the uses of phosphate binders were recorded. Results Within the 3 months before entering INHD, there was no significant difference in average serum phosphate levels. The average phosphorus levels significantly decreased (p<0.05) from 1 month after entering INHD and was steady at <1.67 mmol/L. Hypophosphatemia were detected in 31 cases (6.5%) of 15 patients. It occurred in patients with older age, less body mass index (BMI) and longer NHD duration (p<0.05). After entering INHD, withdrawal of phosphate binders were observed in 14 patients (25%). Conclusion INHD can effectively and stably control hyperphosphatemia in dialysis patients,whit the lower prevalence of  hypophosphatemia .

Key words: nocturnal hemodialysis, Uremia, hyperphosphatemia, hypophosphatemia