Abstract: 【Abstract】 Objective To explore the value of plasma B-type natriuretic peptide in assessing fluid volume in hemodialysis patients. Methods Eighty-seven hemodialysis patients were divided into four groups according to the plasma BNP level. The relationship between plasma BNP level and post-dialysis body weight of MHD patients was analyzed. Results The plasma BNP level and post-dialysis body weight decreased significantly in groups with higher plasma BNP level（p＜0.05）. There was significant difference of BNP and post-dialysis body weight among different groups. The baseline plasma BNP level was positively correlated with decreasing of post-dialysis body weight（R=0.763，p＜0.001）. The changes of post-dialysis body weight, systolic BP, albumin and hemoglobin were correlated with the change of plasma BNP（R=0.823，R2=0.678）.The area under ROC curve was 0.918（p＜0.001）. Conclusions The plasma BNP level could be the effective index to determine chronic volume overload in hemodialysis patients.

Key words: B-type natriuretic peptide, Hemodialysis