Abstract: 【Abstract】Objective To observe the effect of parathyroidectomy on left ventricular hypertrophy of uremic patients with secondary hyperparathyroidism(SHPT). Methods 21 SHPT patients were divided into two groups. 13 patients received parathyroidectomy; 8 patients received regular treatment. Before and 1 year after parathyroidectomy, the serum calcium(Ca), phosphorus(P), parathyroid(iPTH), left ventricular end diastolic diamete(LVED)、interventricular septum diastolic thickness (IVST)，left ventricular posterior wall diastolic thickness(LVPWT), left ventricular ejection fraction (LVEF)were measured, LVMI were calculated. Results The levels of Ca、P、Ca×P、iPTH were decreased after parathyroidectomy(t= -3.823、-3.873、-4.531、-10.545，P <0.01, respectively).The levels of LVMI were decreased from 153.7±56.7g/m2 to 119.5±29.4 g/m2. The effects of parathyroidectomy to LVMI、IVST、LVPWT were signifant (F=4.180、4.174、5.959，P=0.048、0.048、0.019). Conclusion Parathyroidectomy could improve left ventricular hypertrophy of uremic patients with secondary hyperparathyroidism.

Key words: Uremia, Secondary hyperparathyroidism, Parathyroidectomy, left ventricular hypertrophy