Abstract: Objective To retrospectively analyze the therapeutic effect of total parathyroidectomy (TPTX) on uremic patients with secondary hyperparathyroidism (SHPT). Methods Seventy SHPT patients treated with T-PTX in our hospital were enrolled in this study. Serum parathyroid hormone (PTH), calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) obtained in the preoperative, postoperative and followup periods were collected and compared. Their symptoms, postoperative complications and relapse were recorded. Results ①T- PTX operation performed successfully in 67/70 patients (95.7%). ①After T- PTX, bone pain, itching, weakness, insomnia and anorexia improved rapidly, with the improvement of nutritional status. Ten cases can walk freely without wheelchair within one year after T-PTX. ③Serum PTH, Ca, P, and ALP decreased significantly after PTX for one week, one month and 6 months as compared with those before PTX (P＜0.05).④ Hoarseness was found in 2 cases (2.85%) in postoperative period, and improved spontaneously within one week. Postoperative hypocalcemia was frequently seen (59/70, 84.3%) but could be effectively controlled by intravenous calcium infusion. ⑤ SHPT recurred in the 6 months after T- PTX in 2 cases
(2.9%). One of them accepted PTX again, and PTH decreased to 15.0 pg/ml after the operation. Conclusion T-PTX can effectively decrease PTH level and improve symptoms, and is a safe measure for the treatment of uremic patients with SHPT.

Key words: Uremic, Secondary Hyperparathyroidism, Parathyroidectomy