Abstract: Objective To improve the abnormal changes of calcium and phosphorus and intact parathyroid hormone (iPTH) in maintenance hemodialysis (MHD) patients using high flux hemodialyzer. Methods In a total of 82 MHD patients the hemodialyzer for hemodialysis was changed from low flux hemodialyzer to high flux hemodialyzer for 3 months. Serum calcium, phosphorus and iPTH were compared before and after using high flux hemodialyzer. Patients were further divided into parathyroid hyperplasia group and normal parathyroid group based on the findings from Doppler ultrasonography. Serum calcium, phosphorus and iPTH
were further compared between the two groups. Results After using high flux hemodialyzer, serum calcium levels increased (t =-4.786, P＜0.05), and phosphorus and iPTH decreased (t =2.341, P＜0.05 for phosphorus; t =2.937, P＜0.05 for iPTH). These effects were more prominent in parathyroid hyperplasia group than in normal parathyroid group (t =-3.583/-3.207 P=0.001/0.003 for serum Ca; t =1.74/1.619, P =0.089/0.113 for serum P; t =2.408/1.830, P=0.001/0.074 for serum iPTH). Conclusion High flux hemodialyzer was better than low flux hemodialyzer to improve serum calcium and phosphorus and iPTH changes in MHD patients.

Key words: Blood purification, High-fux-hemodialyzer, Calcium, Phosphorus, Parathyroid hormone