Abstract: 【Abstract】Objective To observe the effect of a parathyroidectomy on health-related quality of life in uremic patients with secondary hyperparathyroidism. Methods Thirty uremic patients under hemodialysis therapy receiced a parathyroidectomy for secondary hyperparathyroidism.They were prospectively studied the serum calcium(Ca),phosphorus(P),the product of calcium and phosphorus(Ca×P),parathyroid(iPTH) before and 1 year after parathyroidectomy. Throughout the follow-up period, all subjects completed the Kidney Disease Quality of Life Short Form-36 (KDQOL SF-36) questionnaire at before and 1 year after parathyroidectomy. Results Serum levels of iPTH,calcium,phosphorus and Ca×P were lower at 1 year after treatment compared with that before parathyroidectomy (tiPTH=-9.563,P=0.000,tp=-5.994,P=0.000,tca×p=-7.197,P=0.000,tca= -4.928,P=0.000). SF-36（61.3±19.6 VS 51.2±24.5, t=2.456,P=0.021） and overall health rating(OHR，73.8±11.1VS 65.8±15.2, t=2.699,P=0.012) of our study were increased at one year after parathyroidectomy.There were significant improvement among physically associated problems such as physical function(PF, 56.5±27.0 VS 51.8±32.1,P<0.05)、role-physical(RP, 48.2±41.9 VS 28.5±40.1,P<0.05)、bodily pain(BP, 66.1±26.7 VS 53.6±27.9,P<0.05)、general health(GH, 50.4±22.1 VS 40.6±23.6,P<0.05)、symptom/problems(SP,85.8±10.5VS 73.8±11.1, P<0.05)、effects of kidney disease(EKD,77.1±16.6 VS 65.3±20.7,P<0.01) and sleep (75.1±23.0 VS 58.9±24.5, P<0.01). Conclusion Parathyroidectomy could improve health-related quality of life among hemodialysis patients with secondary hyperparathyroidism.

Key words: Uremia, Secondary hyperparathyroidism, Parathyroidectomy, Quality of life