Abstract: Objective To investigate the effect of highflux dialysis with different ultrafiltration volume on the clearance of uremia toxins and the uremic pruritus in uremic patients. Methods Eighty patients were randomly divided into high ultrafiltration volume group and routine ultrafiltration volume group. All patients underwent highflux dialysis thrice weekly and were followed up for six months. The levels of blood creatinine (Cr), phosphate, β2- microglobulin, and parathyroid hormone (PTH) were tested, and solute clearance was calculated before and after the dialysis. Skin itch degree was evaluated by the improved Duo scale system. Transmembrane pressure and adverse events were monitored during the treatment. Results There was no significant difference in the decrease of Cr between high ultrafiltration volume group and routine ultrafiltration volume group (t=1.094, P=0.277), but the decreases of phosphate and β2-microglobulin were more prominent in high ultrafiltration volume group than in routine ultrafiltration volume group (t=-2.138 and -12.815, respectively; P=0.036 and 0.01, respectively). Skin itch improved more in high ultrafiltration volume group than in routine ultrafiltration volume group (t=-3.556, P=0.010). The prevalence of adverse events was statistically insignificant between the two groups (χ2= 0.346, 0.157 and 0.125, respectively; P=0.556, 0.692 and 0.723, respectively), but the transmembrane pressure was higher in high ultrafiltration volume group than in routine ultrafiltration volume group (t=10.22, P=0.001). Conclusion Highflux dialysis with higher ultrafiltration volume increased the clearance of macro and middle molecule toxins, while uremic pruritus was also alleviated significantly.

Key words: high permeable dialysis , clearance rate , middle molecule , pruritus