Abstract: 【Abstract】Objective To observe the impact of parathyroidectomy (PTX) on calcium and phosphorus metabolism, arterial calcification and arterial stiffness in maintenance hemodialysis (MHD) patients complicated with secondary hyperparathyroidism (SHPT). Methods A total of 21 MHD patients with SHPT were subjected to PTX. Their coronary artery calcification score based on the multi-slice spiral CT images, brachial-ankle pulse wave velocity (baPWV), serum calcium, phosphorus, calcium-phosphorus product, and serum PTH were compared before PTX and after PTX for one year. Results After PTX for one year, coronary artery calcification score decreased significantly (P=0.0236), so did the mean baPWVs of bilateral limbs (P=0.0034 and 0.0012 for left and right limbs, respectively), as compared with those before PTX. Serum calcium, phosphorus, calcium-phosphorus product, and PTH also reduced after PTX (P=0.0004, 0.0002, <0.0001 and <0.0001, respectively). Conclusions PTX improved calcium and phosphorus metabolism, and reduced arterial calcification and stiffness in MHD patients with SHPT.

Key words: hemodialysis, secondary hyperparathyroidism, parathyroidectomy, coronary artery calcification score, brachial-ankle pulse wave velocity