Abstract: Objective T o investigate the factors affecting left ventricular hypertrophy (LVH) in endstage renal disease patients with hemodialysis (HD). Method A total of 175 HD patients treated in the Kidney Disease Center were enrolled in this cross-section study. General information, laboratory measurements, and ultrasonography data for left ventricular hypertrophy were collected. Patients were divided into two groups according to left ventricular mass index (LVMI), left ventricle thickening (LVT) group (n=90) and normal left ventricle group (n=85). General information and laboratory findings were analyzed between the two groups, and the factors affecting LVH were analyzed using Spearman rank correlation and multivariate linear regression. Results Age and systolic pressure were significantly higher and hemoglobin was significantly lower in LVT group than in normal left ventricle group (P＜0.05). Spearman rank correlation indicated that LVH was positively correlated with age, hypertension history, diabetes mellitus history, systolic pressure, and fasting blood glucose (r=0.192, 0.237, 0.173, 0.284 and 0.198, respectively; P＜0.05). LVH was negatively correlated with dialysis age and Kt /V (r= -0.184 and -0.233, respectively; P＜0.05). Multivariate linear regression
showed that age, hypertension history, systolic pressure and Kt/V correlated with LVH (β=0.165, 0.205, 0.196 and -0.184, respectively; P＜0.05). Conclusion Older age, higher systolic pressure, and hypertension history were the risk factors for LVH, while sufficient Kt/V was a protective factor. Control of systolic pressure and sufficient dialysis may reduce the prevalence of LVH.

Key words: hemodialysis, left ventricular hypertrophy, cardiovascular disease, hypertension