Abstract: Objective To compare the effect of peritoneal dialysis (PD) and continuous vena-vena hemodialysis/ hemofiltration (CVVH) on the patients with bee venom-induced multiple organ dysfunction syndrome(MODS). Methods We retrospectively reviewed 30 cases with bee venom-induced MODS, among whom 12 patients were treated with PD (PD group) and 18 patients with CVVH (CVVH group). Clinical data including age, sex, dialysis type, disease severity (APACHEⅡ score), Hb, WBC, serum Cr, ALT, TBil and CK, dialysis related complications, and dialysis expenses per day were collected. Results There were no differences
in age, sex, disease severity, and serum biochemical changes between the two groups (P＞0.05), nor in renal recovery rate and mortality between the two groups (P＞0.05). However, dialysis related complications were found in 55% patients in CVVH group, but was only 15.3% patients in PD group (P＞0.05). Therapeutic doses (58.68±12.53 L/d vs. 11.45±6.62 L/d, P＞0.05), dialysis duration (7.25±9.65 L/d vs. 13.23±11.75 d, P＞0.05), and daily ultrafiltration volume (3264.3±1421.68 ml/d vs. 1747.36±826.14 ml/d, P＞0.05) were significantly different between CVVH group and PD group. Patients in the two groups were followed up for 3 months. Kaplan- Meier survival curves showed no overall survival difference between the two groups (P＞0.05). Dialysis expenses per day were 6020.34±1201.32 yuan in CVVH patients, higher than 592.92±138.62 yuan in PD patients. Conclusion CVVH and PD had similar effect in treatment of bee venom- induced MODS. PD is simpler and less expenses than CVVH. Therefore, PD should be used as the preferential method for bee venom-induced MODS.

Key words: bee venom—induced multiple organ dysfunction syndrome, Peritoneal dialysis, Continuous vena- vena hemodialysis/ hemofiltration