Abstract: 【Abstract】Objective To observe the abnormal bone mineral density (BMD) in maintenance hemodialysis (MHD) patients, and to correlate BMD with age, sex, dialysis vintage, and bone metabolic related indicators including serum iPTH, calcium and phosphorus. Methods This was a cross-sectional study to measure
BMD value by quantitative ultrasound in 263 MHD patients and to observe their age, gender, dialysis vintage, and bone metabolism related indicators. Results ①Abnormal BMD was found in 90.12% MHD patients, including osteoporosis in 45.62% patients and low bone mass in 44.48% patients. ②Age was negatively correlated with BMD value (r=-0.242, P=0.000). The risk of osteoporosis increased 1.352 folds with the increase of age. The prevalence of osteoporosis was 58.62% in females significantly higher than that in males (34.69%; χ2=14.980, P=0.000). The risk of osteoporosis in females was 2.46 times higher than that in males. Hemodialysis vintage was negatively correlated with BMD value (r=-0.198, P=0.198). The risk of osteoporosis increased 1.33 folds with the increase of serum phosphorus. Conclusion The prevalence of abnormal BMD was higher in MHD patients. Age, female, hemodialysis vintage and hyperphosphatemia were the risk factors for osteoporosis.

Key words: Maintenance hemodialysis, Bone mineral density