Abstract: 【Abstract】Objective To observe the change pattern of intraocular pressure and the effect of hemodialysis and hemofiltration on intraocular pressure in maintenance hemodialysis (MHD) patients. Methods A total of 78 MHD patients treated in Beijing Hospital were divided into hemodialysis group (n=63) and hemofiltration group (n=15). Systolic and diastolic blood pressure and the derived average artery pressure were measured before and after dialysis. The dehydration volume after dialysis was calculated. Intraocular pressure at supine position was recorded before dialysis, after the initiation of dialysis for 2 hours, and after dialysis. Osmotic pressure, hemoglobin, hematocrit, serum creatinine (Scr), blood urea nitrogen (BUN), blood glucose and sodium were assayed before and after dialysis. t-test and Pearson correlation analysis were used for statistical analyses. Results Systolic blood pressure and average artery pressure decreased remarkably after dialysis in both groups. Intraocular pressure increased at the beginning of dialysis then decreased afterwards to a level lower than that before dialysis in both groups. Intraocular pressure after the treatment was significantly lower than that during dialysis in hemodialysis group (P＜0.01), but was unchanged in hemofiltration group. Changes of Scr and BUN after dialysis were significantly higher in hemodialysis group than in hemofiltration group (P＜0.01), but changes of other blood biochemistry parameters were similar between the two groups. The decrease of intraocular pressure in right and left eyes was positively correlated with the dehydration volume after dialysis (r=0.305 and 0.343, respectively; P＜0.05). Conclusions Intraocular pressure increased at the beginning of dialysis then decreased afterwards in both groups. Intraocular pressure at the end of dialysis was lower than that before dialysis. Intraocular pressure during dialysis increased more in hemodialysis group and stabilized significantly in hemofiltration group, suggesting that hemofiltration resulted in less hemodynamics disturbances and thus less intraocular pressure changes.

Key words: Hemodialysis, Hemofiltration, Intraocular pressure