Abstract: 【Abstract】Objective To explore the effect of lanthanum carbonate on vascular calcification in maintenance hemodialysis (MHD) patients without diabetes. Methods A total of 60 MHD patients treated in Beijing Chaoyang Hospital were divided into two groups, the calcium carbonate (CC) group and the lanthanum carbonate (LC) group. We compared the indices of serum calcium, phosphate, fibroblast growth factor - 23 (FGF23), homocysteine, endothelin, matrix gla protein (MGP), hsCRP, lipids, etc., and evaluated the coronary artery calcification score (CACS) by multi-slice spiral computed tomography at baseline and after the treatment for 12 months. SPSS 17.0 for Windows was used for statistical analyses. Results Serum calcium, phosphate, FGF23 and MGP decreased significantly and serum endothelin increased significantly in LC group after 12 months therapy as compared with those at baseline (P＜0.05). In contrast in CC group, serum phosphate and MGP decreased significantly, serum calcium and endothelin increased significantly (P＜0.05), but FGF23 was unchanged after the treatment for 12 months. When comparisons were made between the two groups, serum calcium, phosphate and FGF23 were significantly lower and MGP were significantly higher in LC group than in CC group (P＜0.05). Pearson’s correlation analyses revealed that the change of CACS was negatively correlated with the changes of serum phosphate and FGF23, and was positively correlated with the change of serum MGP in MHD patients without diabetes (P＜0.05). Changes of serum phosphate and FGF23 were the independent influence factors for CACS change. Conclusions CACS progressed slower in LC group than in CC group. Lanthanum carbonate can decrease serum phosphate, FGF23 but not increase serum calcium as compared with calcium carbonate. In addition, lanthanum carbonate can influence serum MGP level in MHD patients without diabetes.

Key words: maintenance hemodialysis, vascular calcification, lanthanum carbonate